The thermodynamic influence of trapped water molecules on a protein-ligand interaction.
نویسندگان
چکیده
Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein-ligand interaction.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 48 28 شماره
صفحات -
تاریخ انتشار 2009